Here’s What Happens to People Who Stay on Wegovy Long Term

issue from the longest - running tryout of semaglutide — the active ingredient in the pop drugs Ozempic and Wegovy — are in , and the verdict is unquestionably positive . The bailiwick found that people necessitate semaglutide tended to keep their initial weight loss for up to four yr . Other trial data presented this week also suggest that semaglutide can improve people ’s heart health even without causing weightiness departure .

Last summer , the makers of semaglutide , Novo Nordisk , reportedthe chief determination of the SELECT trial . The trial involved over 17,000 people and tested whether the drug could help heavy or obese individual without diabetes but with pre - existing cardiovascular disease . The trial incur that in high spirits - battery-acid semaglutide cut the risk of major cardiovascular events by 20 % for up to five years when liken to a placebo .

The newfangled research , publishedMonday in Nature Medicine , specifically analyze the weight loss final result of those in the SELECT trial . On average , people demand semaglutide lost about 10 % of their baseline system of weights within 65 weeks , far more than those on placebo , according to the study . By year four , these solution remain remarkably consistent , with an modal 10.2 percent exercising weight loss discover in patient still taking the drug .

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“ These information , representing the longest clinical trial of the effects of semaglutide versus placebo on weight , establish the safety and durability of semaglutide effects on weight deprivation and care in a geographically and racially divers universe of adult men and adult female with overweight and corpulency but not diabetes , ” the authors of the Nature Medicine paper wrote .

The consequence are somewhat less telling than other clinical test of high - dose semaglutide , which have shown outcomes hovering around 15 percent weight loss on average . And not everyone taking the drug in the test miss significant exercising weight or needfully maintained their weight unit loss four years later . But the information does betoken that semaglutide and other related GLP-1 drug generally can be assume over the long draw without losing their effectiveness or causing serious trouble .

GLP-1 drugs are known to make vulgar gastrointestinal side upshot such as vomiting and diarrhea , though some datum has suggested that these side effect become less common over time . And in the SELECT run , the risk of serious adverse events after four years was actually lower in the semaglutide group than placebo — in all probability due to the drug ’s effect on improving cardiovascular wellness , the authors say .

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Obesity can raise citizenry ’s risk of cardiovascular disease , and it ’s likewise thought that much of the spunk benefit provided by these drugs come from serve people lose clinically meaning amounts of free weight and trunk fat . But another analytic thinking of the SELECT test pose this week , at the European Congress of Obesity , suggests that things are more complicated than that . This study found that mass on semaglutide be given to experience few cardiovascular event no matter their start weight or if they lost much weight at all .

“ Our findings show that the magnitude of this handling core with semaglutide is self-governing of the amount of weight lost , suggesting that the drug has other actions which lower cardiovascular risk beyond reducing unhealthy consistency fatty tissue , ” said John Deanfield , a research worker from University College London who go the 2nd subject , in astatementfrom the European Association for the Study of Obesity . “ These substitute mechanisms may include positive impact on blood gelt , rake pressure , or fervor , as well as direct force on the heart muscle and blood vessels , or a compounding of one or more of these . ”

The results of both studies are likely to bolster attempts to expand insurance policy insurance coverage of these drug , which are expensive and often not cover by secret or public payers .

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